IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN EXPRESSION IN HPV-INDUCED CONDYLOMA ACUMINATUM

Immunohistochemical peroxidase staining for p53 protein was performed on 22 condyloma acuminatum tissue samples from patients infected with human papillomavirus (HPV), The purpose of our study was to understand the;benign character of this syndrome. The patients studied were infe cted by HPV type 6 and 11. Two monoclonal antibodies, PAbs DO-1 and 24 0, were used to detect the p53 protein, Overexpression of wild-type p5 3 was found in the nuclei of the basal cell layers, In healthy tissues and non-infected patients no p53 protein expression was detected, We would like to speculate that infection with HPVs and their viral prote in E7, which is implicated in disruption of normal growth, may regulat e the induction of wild-type p53 overexpression, as is known for DNA-d amaging agents such as UV- or X-radiation.