Forty-three human cadavers underwent single-portal endoscopic carpal t
unnel release using the Agee technique. Subsequent independent open di
ssection revealed complete release of all potentially compressing tran
sverse structures in 19 specimens and incomplete release in 24 specime
ns. There were 2 specimens with vascular injuries; one transection of
a perforating branch of the palmar arch, and one transection of the ul
nar artery at the entry portal. The 43 specimens were divided into thr
ee groups: group 1 (13 specimens) were released by the senior author i
n 1989; group 2 (13 specimens) were released by the senior author in 1
992; and group 3 (17 specimens) were released by surgeons learning the
technique under direct supervision of the senior author. Complete rel
ease was 5 of 13 for group 1, 6 of 13 for group 2, and 8 of 17 for gro
up 3. This study indicates that incomplete release is an inherent feat
ure of this technique regardless of the surgeon's experience and despi
te blade redesign. The significance of incomplete release is unknown a
nd must be determined in long-term clinical studies.