SYNTHESIS OF OLIGONUCLEOTIDES BEARING THE NONSTANDARD BASES ISO-C ANDISO-G - COMPARISON OF ISO-C-ISO-G, C-G AND U-A BASE-PAIR STABILITIES IN RNA DNA DUPLEXES/

Authors
ROBERTS C BANDARU R SWITZER C
Citation
C. Roberts et al., SYNTHESIS OF OLIGONUCLEOTIDES BEARING THE NONSTANDARD BASES ISO-C ANDISO-G - COMPARISON OF ISO-C-ISO-G, C-G AND U-A BASE-PAIR STABILITIES IN RNA DNA DUPLEXES/, Tetrahedron letters, 36(21), 1995, pp. 3601-3604
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
21
Year of publication
1995
Pages
3601 - 3604
Database
ISI
SICI code
0040-4039(1995)36:21<3601:SOOBTN>2.0.ZU;2-J
Abstract
The synthesis of iso-cytidine and 2'-deoxy-iso-guanosine phosphoramidi tes in protected form is described. The synthesis of complementary dod ecanucleotides containing a central iso-C-iso-G base-pair was achieved . It is found that the iso-C-iso-G base-pair has comparable stability to a C-G base-pair.