THE PROTECTIVE EFFECT OF MONOCLONAL ANTI- IDIOTYPICAL ANTIBODIES IN AN EXPERIMENTAL HERPETIC INFECTION

Authors
NAGHIYEVA FG BARKOVA YP NIKULINA VG KRASNOVA NI ANDZHAPARIDZE OG
Citation
Fg. Naghiyeva et al., THE PROTECTIVE EFFECT OF MONOCLONAL ANTI- IDIOTYPICAL ANTIBODIES IN AN EXPERIMENTAL HERPETIC INFECTION, Voprosy virusologii, 40(2), 1995, pp. 70-72
Citations number
NO
Categorie Soggetti
Virology
Journal title
Voprosy virusologii → ACNP
ISSN journal
05074088
Volume
40
Issue
2
Year of publication
1995
Pages
70 - 72
Database
ISI
SICI code
0507-4088(1995)40:2<70:TPEOMA>2.0.ZU;2-V
Abstract
The protective effect of monoclonal anti-idiotypical antibodies m(anti -ID)Abs, simulating the biologic effects of human alpha interferons, w ere studied in male guinea pigs with genital herpes simplex, Therapeut ic effect of m(antu-ID)Abs daily applied as liquid dosage form and as suppositoria was assessed. Experiments demonstrated that m(antu-ID)Abs in liquid dosage form to a different measure decreased tile severity of urogenetal infection in guinea pigs and that m(anti-ID)Abs-25 compl etely prevented the development of grave infection.