CIRCADIAN-RHYTHMS OF LIPID AND APOLIPOPROTEIN PATTERN IN ADULT FASTEDRATS

Data on circadian rhythms of serum lipids and apolipoproteins in anima ls and in human subjects are scarce. The goal of this study was to inv estigate the existence of circadian rhythms in the lipids and apolipop roteins of fasted rats. We showed that in fasted rats well-defined cir cadian rhythms were present in total serum triglycerides and in choles terol and triglycerides of very low density lipoprotein (VLDL), interm ediate density lipoprotein-low density lipoprotein (IDL-LDL) and high density lipoprotein (HDL). Moreover, our data clearly show that the ci rcadian rhythm of lipoproteins is accompanied by a well defined circad ian rhythm of B apoprotein, in all lipoprotein classes examined.