Kl. Lutz et Tj. Siahaan, E-CADHERIN PEPTIDE SEQUENCE RECOGNITION BY ANTI-E-CADHERIN ANTIBODY, Biochemical and biophysical research communications, 211(1), 1995, pp. 21-27
Cadherins are calcium dependent glycoproteins involved in hemophilic c
ell-cell adhesion. To further elucidate the interaction between cadher
ins we have developed an immobilized peptide ELISA to quickly scan the
extracellular domains of E-cadherin. Peptides displaying antigenic re
activity to anti-E-cadherin antibody are presumably on the surface and
thus may be involved in cadherin-cadherin interaction. We have found
three peptides from the EC-1 domain which are recognized by the anti-E
-cadherin antibody. These peptides are in the two important regions of
the EC-1 domain that was deduced hom its secondary structure. (C) 199
5 Academic Press, Inc.