TRANSCRIPTION INITIATION IS LOCALIZED TO A TATALESS REGION IN THE OVINE BETA-1 ADRENERGIC-RECEPTOR GENE

Authors
PADBURY JF TSENG YT WASCHEK JA
Citation
Jf. Padbury et al., TRANSCRIPTION INITIATION IS LOCALIZED TO A TATALESS REGION IN THE OVINE BETA-1 ADRENERGIC-RECEPTOR GENE, Biochemical and biophysical research communications, 211(1), 1995, pp. 254-261
Citations number
28
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
211
Issue
1
Year of publication
1995
Pages
254 - 261
Database
ISI
SICI code
0006-291X(1995)211:1<254:TIILTA>2.0.ZU;2-7
Abstract
We cloned and sequenced the ovine beta, adrenergic receptor (beta(1)AR ) gene and promoter region. The transcription start site was localized by RNase protection and primer extension to a GC-rich region. The pre dominant initiation sequence did not resemble an initiator element and there was no upstream TATA box. Sequence analysis revealed several po tential thyroid hormone and glucocorticoid regulatory elements. Identi fication of the promoter structure of this important gene will help de fine its novel regulation during development. (C) 1995 Academic press, Inc.