MODEL SYSTEMS FOR STUDY OF GENETIC-FACTOR S IN CARCINOGENESIS

The steadily rising public concern about the number and amounts of car cinogenic agents in our environment has led to a decline in interest i n another aspect of tumorigenesis, namely the involvement of genetic f actors in the processes that lead to malignant tumors. It is becoming evident that both the noxious influences in the environment and the ge netic make-up of cells or the whole individual are involved in cancero us processes to a similar extent. The usefulness of experimental anima l models for analysis of the extreme complexity of the molecular mecha nisms underlying tumor formation is demonstrated by recent results in experimental oncology.