Two patients with Sjogren-Larsson syndrome were treated with calcipotr
iol in ointment and the ointment base only for 12 weeks, using a doubl
e-blind bilaterally paired comparative study. Unilateral improvement w
as observed in both patients in favour of the calcipotriol-treated sid
e. The present case is the first demonstration of a substantial clinic
al effect of calcipotriol in the Sjogren-Larsson syndrome.