FINAL REPORT OF A PHASE-II STUDY OF INTERLEUKIN-2 AND INTERFERON ALPHA IN PATIENTS WITH METASTATIC MELANOMA

Authors
KRUIT WHJ GOEY SH CALABRESI F LINDEMANN A STAHEL RA POLIWODA H OSTERWALDER B STOTER G
Citation
Whj. Kruit et al., FINAL REPORT OF A PHASE-II STUDY OF INTERLEUKIN-2 AND INTERFERON ALPHA IN PATIENTS WITH METASTATIC MELANOMA, British Journal of Cancer, 71(6), 1995, pp. 1319-1321
Citations number
18
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
71
Issue
6
Year of publication
1995
Pages
1319 - 1321
Database
ISI
SICI code
0007-0920(1995)71:6<1319:FROAPS>2.0.ZU;2-B
Abstract
Fifty-seven patients with metastatic melanoma were treated with interl eukin 2 (IL-2) 7.8 MIU m(-2) day(-1) as a continuous infusion for 4 da ys combined with interferon alpha (IFN-alpha) 6 MIU m(-2) day(-1) subc utaneously on days 1 and 4. The cycle was repeated every 2 weeks for a maximum number of 13 cycles. Of the 51 evaluable patients, one (2%) a chieved a complete and seven (14%) a partial response (total response rate 16%; Cl 7-29%). Median time to progression and median survival we re 2.5 and 11.3 months respectively. This regimen of IL-2 and IFN-alph a appeared to be only moderately active.