KARYOTYPIC EVOLUTION IN A GRANULOCYTIC SARCOMA DEVELOPING IN A MYELOPROLIFERATIVE DISORDER WITH A NOVEL (3-4) TRANSLOCATION

Authors
MYINT H CHACKO J MOULD S ROSS F OSCIER DG
Citation
H. Myint et al., KARYOTYPIC EVOLUTION IN A GRANULOCYTIC SARCOMA DEVELOPING IN A MYELOPROLIFERATIVE DISORDER WITH A NOVEL (3-4) TRANSLOCATION, British Journal of Haematology, 90(2), 1995, pp. 462-464
Citations number
7
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
90
Issue
2
Year of publication
1995
Pages
462 - 464
Database
ISI
SICI code
0007-1048(1995)90:2<462:KEIAGS>2.0.ZU;2-2
Abstract
A 59-year-old man presented with a granulocytic Intensive chemotherapy and local radiotherapy led to sarcoma arising in the manubrium, and s plenomegaly. The blood count showed 1.2 x 10(9)/l eosinophils and a ma rrow chromosome aspirate was hypercellular with eosinophilia. Cytogene tic analysis of the marrow revealed a novel t(3;4) (p13;q12) and analy sis of cells aspirated from the granulocytic sarcoma showed the same a bnormality and an additional trisomy 8. Intensive chemotherapy and loc al radiotherapy led to resolution of the chest mass but persistence of the chromosome translocation in the marrow.