CONTROL OF MYOCARDIAL REPERFUSION INJURY WITH HYPERTONIC-HYPEROSMOTICSOLUTION IN ISOLATED RABBIT HEART

The effects of postischemic reperfusion were investigated in 14 isolat ed rabbit hearts in Langendorff preparation. Seven were controls and t he others were reperfused with a sodium 7.5% and dextran 60 (60,000 MW ) solution diluted with Krebs-Henseleit buffer to a sodium concentrati on of 150 mEq/1. The incidence of arrhythmias was lower in this group (p = 0.034). Coronary flow was higher than in controls (p = 0.035), th e levels of isoenzyme MB of creatine kinase were lower than in control s (p = 0.035), myocardial water content was also lower (p = 0.047), an d histological damage was reduced (p = 0.018). It was concluded that e arly reperfusion with 7.5% sodium chloride, 6% dextran 60 solution has a protective effect in the treatment of cardiac reperfusion injury.