F. Chryssomallis et al., STEROID-PULSE THERAPY IN PEMPHIGUS-VULGARIS LONG-TERM FOLLOW-UP, International journal of dermatology, 34(6), 1995, pp. 438-442
Background. Patients with pemphigus vulgaris may occasionally present
the highly active, widespread form of the disease, and/or maybe resist
ant to conventional oral steroid therapy, and/or manifest significant
side effects from the prolonged use of high oral prednisone dosage. Ou
r purpose was to evaluate the efficacy of steroid ''pulse'' therapy (P
T) in these patients. Methods. Eight patients were given alternate-day
, one hour, infusions of 8, 9, or 10 mg/kg methylprednisolone Na succi
nate. Oral prednisone and a second immunosuppressive agent were simult
aneously administered; these were rapidly decreased when control of th
e disease was achieved. Results. All patients initially responded well
to therapy. The disease recurred in four patients after 3, 4, 9, and
16 months of remission, respectively. Three of these patients were tre
ated again with pr and went into remission. None of the patients who r
eceived cyclophosphamide had a recurrence. One patient died of cardiac
arrest, 12 days after PT. On a follow-up of 59 +/- 25 months since th
e last relapse, patients continue in remission. Conclusions. Pulse the
rapy is recommended as an adjunct to the total management plan of seve
rely affected patients with pemphigus vulgaris. The addition of cyclop
hosphamide may prevent the disease from recurring. Alternate-day small
-quantity bolus infusions over 16-20 days, may be equally effective as
the administration of 15 mg/kg/daily for 3-5 days. The risk of cardia
c arrest exists even with this, less aggressive form of PT therapy. A
medical history of supraventricular arrhythmias may be considered a ri
sk factor.