STEROID-PULSE THERAPY IN PEMPHIGUS-VULGARIS LONG-TERM FOLLOW-UP

Citation
F. Chryssomallis et al., STEROID-PULSE THERAPY IN PEMPHIGUS-VULGARIS LONG-TERM FOLLOW-UP, International journal of dermatology, 34(6), 1995, pp. 438-442
Citations number
18
Categorie Soggetti
Dermatology & Venereal Diseases
ISSN journal
00119059
Volume
34
Issue
6
Year of publication
1995
Pages
438 - 442
Database
ISI
SICI code
0011-9059(1995)34:6<438:STIPLF>2.0.ZU;2-E
Abstract
Background. Patients with pemphigus vulgaris may occasionally present the highly active, widespread form of the disease, and/or maybe resist ant to conventional oral steroid therapy, and/or manifest significant side effects from the prolonged use of high oral prednisone dosage. Ou r purpose was to evaluate the efficacy of steroid ''pulse'' therapy (P T) in these patients. Methods. Eight patients were given alternate-day , one hour, infusions of 8, 9, or 10 mg/kg methylprednisolone Na succi nate. Oral prednisone and a second immunosuppressive agent were simult aneously administered; these were rapidly decreased when control of th e disease was achieved. Results. All patients initially responded well to therapy. The disease recurred in four patients after 3, 4, 9, and 16 months of remission, respectively. Three of these patients were tre ated again with pr and went into remission. None of the patients who r eceived cyclophosphamide had a recurrence. One patient died of cardiac arrest, 12 days after PT. On a follow-up of 59 +/- 25 months since th e last relapse, patients continue in remission. Conclusions. Pulse the rapy is recommended as an adjunct to the total management plan of seve rely affected patients with pemphigus vulgaris. The addition of cyclop hosphamide may prevent the disease from recurring. Alternate-day small -quantity bolus infusions over 16-20 days, may be equally effective as the administration of 15 mg/kg/daily for 3-5 days. The risk of cardia c arrest exists even with this, less aggressive form of PT therapy. A medical history of supraventricular arrhythmias may be considered a ri sk factor.