FUROSEMIDE INHIBITS BRADYKININ-INDUCED CONTRACTION OF HUMAN BRONCHI -ROLE OF THROMBOXANE A(2) RECEPTOR ANTAGONISM

Authors
MOLIMARD M NALINE E HIRSCH A ADVENIER C
Citation
M. Molimard et al., FUROSEMIDE INHIBITS BRADYKININ-INDUCED CONTRACTION OF HUMAN BRONCHI -ROLE OF THROMBOXANE A(2) RECEPTOR ANTAGONISM, European journal of pharmacology, 278(3), 1995, pp. 253-256
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
278
Issue
3
Year of publication
1995
Pages
253 - 256
Database
ISI
SICI code
0014-2999(1995)278:3<253:FIBCOH>2.0.ZU;2-2
Abstract
Bradykinin contracts human isolated small bronchi through prostanoid r elease and subsequent TP receptor stimulation. Furosemide 10(-4) to 10 (-3) M concentration dependently inhibited bradykinin- and the stable TP receptor agonist U-46619-induced contraction of human isolated smal l airways. The inhibitory effect of furosemide on U-46619-induced cont raction involves competitive antagonism at TP receptors. Such an inhib ition of TP receptors could a least partly explain the inhibitory effe ct of furosemide on bradykinin-induced contraction, and could be one o f the mechanisms of the protective effect of furosemide in asthma.