Background: Alloimmunization to blood group antigens other than ABH af
ter bone allografting is uncommon,To date, examples of alloimmunizatio
n to blood group antigens other than ABH have been limited to the Rh s
ystem. Case Report: A 20-year-old woman received an allogeneic bone gr
aft following resection of an osteosarcoma, The patient had received n
o blood components and denied any pregnancies, Alloimmunization was de
tected and alloantibodies were identified by standard serologic techni
ques; Fourteen months after the bone graft, anti-Fy(a) and anti-Jk(b)
were identified in her serum. Conclusion: Alloimmunization to blood gr
oup antigens other than ABO and Rh may follow bone allografting.