EXTENSIVE BONE-MARROW NECROSIS ASSOCIATED WITH ANTIPHOSPHOLIPID ANTIBODIES

Bone marrow necrosis (BMN), defined morphologically by destruction of hematopoietic tissue, including the stroma, with preservation of the b one, is a rare syndrome. The conditions in which it is seen include si ckle cell disease, acute leukemia, metastatic neoplasia, and bacterial infection, particularly when hypovolemia and septic shock are present . BMN is also associated with disseminated intravascular coagulation ( DIC) following irradiation and antineoplastic therapy. The antiphospol ipid syndrome (APS) is characterized by antibodies directed against th e antiphospolipid substrate. Because this substrate is prominently inv olved in the coagulation cascade and widely distributed on cell walls, patients present with venous or arterial thromboses, recurrent aborti on, thrombocytopenia, and Coombs' positive hemolytic anemia, typically with raised anticardiolipin antibodies or a diagnostic lupus anticoag ulant test. BMN does not appear to have been previously recognized in this context. We report what we believe to be the first such case and suggest that the high titers of antibodies present may have played a c entral role in its pathogenesis.