SECRETION OF GASTRIC-INHIBITORY POLYPEPTIDE IN PATIENTS WITH BILE-DUCT OBSTRUCTION

Background: The direct contribution of bile to gastric inhibitory poly peptide (GIP) release and the role of bile in regulating GIP secretion in response to fat ingestion are still obscure. The present study was aimed to clarify the influence of bile on GIP release. Methods: Seven patients with obstruction of the common bile duct and nine volunteers participated in the study. Fifty milliliters of Lipomuli(R) was inges ted, and GIP was measured serially for 180 min. After intraduodenal in stillation of pooled autologous bile for 2 days, the same study was ca rried out. Results: The fat-stimulated GIP response was significantly lower in the patients than in the controls. The basal GIP level did no t change on bile instillation, but the GIP response to fat ingestion w as significantly increased on bile instillation compared with that in the absence of bile. Conclusions: Intraluminal bile alone does not sti mulate the secretion of GIP, but it promotes GIP secretion in response to fat ingestion.