Good analgesia does not normalize post-operative pulmonary function bu
t is important in allowing measures such as post-operative physiothera
py to be applied following major abdominal or thoracic surgery. Clinic
al studies have generally failed to duplicate animal work on the effec
tiveness of pre-emptive analgesia possibly because the nociceptor stim
uli persist as long as there is wound pain. Anaesthetic techniques whi
ch include sensory blockade are associated with a lower incidence of s
everal post-operative complications and this improvement is more marke
d in high-risk patients. The contributions of spinal opioids to this i
s not known. Long-lasting analgesia can be provided via a catheter ins
erted in a relevant neurovascular compartment. There is no evidence th
at multimodal 'balanced' analgesia offers any advantages in terms of i
mproved outcome or reduction in adverse events. Whilst sophisticated m
ethods for providing post-operative pain relief, such as PCA and PCEA,
are highly effective, they are appropriate for only a minority of sur
gical operations. An Acute Pain Service can delivery a traditional int
ermittent opioid regime effectively at relatively low cost.