Primordial nucleosynthesis has established itself as one of the three
pillars of Big Bang cosmology. Many of the Big Bang Nucleosynthesis re
actions involve unstable nuclei. Hence, there is a tight relationship
between the subject of this conference and cosmology. The prime role o
f unstable nuclei in cosmology is related to lithium synthesis and the
lack of cosmological synthesis of Be and B. These nuclei will thus be
focused upon. Nucleosynthesis involves comparing calculated abundance
s with observed abundances. In general abundance determinations are do
minated by systematic rather than statistical errors, and work on boun
ding systematics is crucial. The quark-hadron inspired inhomogeneous c
alculations now unanimously agree that only relatively small variation
s in Omega(b) are possible vis-a-vis the homogeneous model; hence, the
robustness of Omega(b) similar to 0.05 is now apparent. (These calcul
ations depend critically on unstable nuclei.) The above argues that th
e bulk of the baryons in the universe are not producing visible light.
A comparison with the ROSAT cluster data is also shown to be consiste
nt with the standard BBN model. Omega(b) similar to 1 seems to be defi
nitely excluded, so, if Omega(TOTAL) = 1, as some recent observations
may hint, then non-baryonic dark matter is required. The implications
of the recently reported halo microlensing events are discussed. In su
mmary, it is argued that the physics of unstable nuclei affects the fu
ndamental dark matter argument.