PACLITAXEL EFFECT ON A LEUKEMIA-CELL LINE - IMPORTANCE OF PACLITAXEL CONCENTRATION

The efficacy of a drug may be a complex function of the length of drug exposure and the drug concentration. One traditional way to model the se variables together has been to look at the area under the curve (AU G) when drug concentration is plotted against time. Experiments in an HL60 leukemia cell model suggest that, for the antineoplastic drug pac litaxel, AUC is not a good predictor of efficacy.