PULMONARY TOXICITY OF CONTINUOUS-INFUSION 5-FLUORO-2'-DEOXYURIDINE

Authors
CHU SI KIM HJ SKUBITZ KM
Citation
Si. Chu et al., PULMONARY TOXICITY OF CONTINUOUS-INFUSION 5-FLUORO-2'-DEOXYURIDINE, Anti-cancer drugs, 6(3), 1995, pp. 475-478
Citations number
26
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Anti-cancer drugs → ACNP
ISSN journal
09594973
Volume
6
Issue
3
Year of publication
1995
Pages
475 - 478
Database
ISI
SICI code
0959-4973(1995)6:3<475:PTOC5>2.0.ZU;2-9
Abstract
This report describes a patient who developed pulmonary toxicity, mani fest by dyspnea on exertion, a low pO(2), a normal FEV(1) and FVC, and a low DLCO while receiving 5-fluoro-2'-deoxyuridine (FUDR) by intermi ttent continuous i.v. infusion. No other cause of his low DLCO could b e identified. The dyspnea on exertion and DLCO improved gradually afte r the FUDR was discontinued. This case was felt to represent a previou sly undescribed toxicity of the continuous i.v. infusion of FUDR.