Nontraumatic perforation of the small bowel is rare. A 71-year-old man
presented with a perforated jejunum 8 weeks after receiving streptoki
nase therapy for acute myocardial infarction. This was complicated by
a bleeding duodenal ulcer, renal failure, ischemia of one toe and conf
usion. Renal biopsy showed cholesterol emboli. Examination of the rese
cted specimen of jejunum revealed multiple cholesterol emboli but no o
ther disorder. Cholesterol embolization has been associated with angio
graphy, vascular surgery and thrombolytic therapy for myocardial infar
ction. Acute renal failure and ischemia of the digits as seen in this
patient is also a common presentation of cholesterol embolization synd
rome.