SYNTHESIS OF N-6-CYCLOPENTYLADENIN-9-YL)-2-DEOXY-D-ALTROHEXITOL

The N-6-cyclopentyladenosine (CPA) analogue (4) was synthesized in 10 steps starting from glucose. The results of the radioligand binding as says are consistent with the thus far published findings that compound s containing a six-membered moiety at N-9 exhibit extremely weak affin ity for adenosine receptors. Replacement of the ribofuranosyl moiety o f CPA (2) by a 2-deoxy-D-altohexitol moiety is sufficient to completel y abolish its agonist activity.