SYNTHESIS OF 9-(2-HYDROXYETHOXYMETHYL)GUANINE (ACYCLOVIR) FROM GUANOSINE

Authors
SHIRAGAMI H KOGUCHI Y TANAKA Y TAKAMATSU S UCHIDA Y INEYAMA T IZAWA K
Citation
H. Shiragami et al., SYNTHESIS OF 9-(2-HYDROXYETHOXYMETHYL)GUANINE (ACYCLOVIR) FROM GUANOSINE, Nucleosides & nucleotides, 14(3-5), 1995, pp. 337-340
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
337 - 340
Database
ISI
SICI code
0732-8311(1995)14:3-5<337:SO9(FG>2.0.ZU;2-B
Abstract
A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) from guanosine by chemical transpurination was developed. The isomeri zation of the 7-isomer to the desired 9-isomer and the purification of the 9-isomer was achieved simply by concentration, heating and furthe r crystallization.