A NOVEL SYNTHESIS OF MIZORIBINE(R) AND RELATED NUCLEOSIDES FROM ACYCLIC PRECURSORS

Authors
EWING DF HUMBLE RW MACKENZIE G SHAW G
Citation
Df. Ewing et al., A NOVEL SYNTHESIS OF MIZORIBINE(R) AND RELATED NUCLEOSIDES FROM ACYCLIC PRECURSORS, Nucleosides & nucleotides, 14(3-5), 1995, pp. 369-372
Citations number
16
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
369 - 372
Database
ISI
SICI code
0732-8311(1995)14:3-5<369:ANSOMA>2.0.ZU;2-C
Abstract
Mizoribine(R) moyl-1-beta-D-ribofuranosylimidazolium-5-olate)(13 beta) and its 4-cyano analogue (20) were synthesized by formation of a malo namide from 2,3-isopropylidene-D-ribosylamine and a malonic acid deriv ative followed by amination, cyclisation and deprotection steps.