SYNTHESIS OF NOVEL OLEFINIC CARBOCYCLIC PURINE NUCLEOSIDE ANALOGS

Authors
WACHTMEISTER J CLASSON B SAMUELSSON B
Citation
J. Wachtmeister et al., SYNTHESIS OF NOVEL OLEFINIC CARBOCYCLIC PURINE NUCLEOSIDE ANALOGS, Nucleosides & nucleotides, 14(3-5), 1995, pp. 405-408
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
405 - 408
Database
ISI
SICI code
0732-8311(1995)14:3-5<405:SONOCP>2.0.ZU;2-J
Abstract
The synthesis of optically pure unsaturated carbocyclic nucleoside ana logues is described. (3,4S)-Bis(t-butyldiphenyl silyloxymethyl)-1R and 1S cyclopent-2-en-1-ol were coupled with 6-chloropurine and 2-amino-6 -chloropurine respectively, using a modified Mitsunobu reaction. The p roducts were reacted further using standard procedures to give compoun ds 12, 14, 16 and 18.