5-HALO-6-ALKOXY-5,6-DIHYDRO-PYRIMIDINE NUCLEOSIDES - ANTIVIRAL NUCLEOSIDES OR NUCLEOSIDE PRODRUGS

Authors
WIEBE LI KNAUS EE CHERAGHALI AM KUMAR R MORIN KW WANG L
Citation
Li. Wiebe et al., 5-HALO-6-ALKOXY-5,6-DIHYDRO-PYRIMIDINE NUCLEOSIDES - ANTIVIRAL NUCLEOSIDES OR NUCLEOSIDE PRODRUGS, Nucleosides & nucleotides, 14(3-5), 1995, pp. 501-505
Citations number
8
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
501 - 505
Database
ISI
SICI code
0732-8311(1995)14:3-5<501:5N-AN>2.0.ZU;2-W
Abstract
5-Halo-6-alkoxy-5,6-dihydro derivatives of azidothymidine (AZT) and et hyldeoxyuridine (EDU) were developed and evaluated using in vitro and in vivo models. Although most of these 5,6-dihydro derivatives served as prodrugs in improving site-specific delivery and pharmacokinetic pa rameters, some unique characteristics were exhibited.