SYNTHESIS AND ANTIVIRAL EVALUATION OF 3'-DEOXY-BETA-L-ERYTHRO-PENTOFURANOSYL NUCLEOSIDES OF THE 5 NATURALLY-OCCURRING NUCLEIC-ACID BASES

Authors
MATHE C GOSSELIN G BERGOGNE MC AUBERTIN AM OBERT G KIRN A IMBACH JL
Citation
C. Mathe et al., SYNTHESIS AND ANTIVIRAL EVALUATION OF 3'-DEOXY-BETA-L-ERYTHRO-PENTOFURANOSYL NUCLEOSIDES OF THE 5 NATURALLY-OCCURRING NUCLEIC-ACID BASES, Nucleosides & nucleotides, 14(3-5), 1995, pp. 549-550
Citations number
5
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
549 - 550
Database
ISI
SICI code
0732-8311(1995)14:3-5<549:SAAEO3>2.0.ZU;2-U
Abstract
The hitherto unknown title compounds were stereospecifically synthesiz ed by glycosylation of pyrimidine and purine aglycons with a suitably peracylated 3'-deoxy-beta-L-erythro-pentofuranose, followed by removal of the protecting groups. All the prepared compounds were tested for their ability to inhibit the replication of a variety of DNA and RNA v iruses (including HIV), but they did not show significant antiviral ac tivity.