COMBINATION OF AZIDOTHYMIDINE (AZT) AND (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE (BVDU) INHIBITS THE REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1(HSV-1) AND TYPE-2 (HSV-2) AND VARICELLA-ZOSTER VIRUS (VZV) STRAINS THAT ARE DEFICIENT IN THE EXPRESSION OF THE VIRAL THYMIDINE KINASE (TK)

Authors
ANDREI G SNOECK R BALZARINI J DECLERCQ E
Citation
G. Andrei et al., COMBINATION OF AZIDOTHYMIDINE (AZT) AND (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE (BVDU) INHIBITS THE REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1(HSV-1) AND TYPE-2 (HSV-2) AND VARICELLA-ZOSTER VIRUS (VZV) STRAINS THAT ARE DEFICIENT IN THE EXPRESSION OF THE VIRAL THYMIDINE KINASE (TK), Nucleosides & nucleotides, 14(3-5), 1995, pp. 559-562
Citations number
5
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
559 - 562
Database
ISI
SICI code
0732-8311(1995)14:3-5<559:COA(A(>2.0.ZU;2-Z
Abstract
Combinations of high concentrations of AZT with BVDU, acyclovir (ACV) or ganciclovir (GCV) show antagonism against TK+ HSV-1, but not TK+ VZ V strains, in cell cultures. When BVDU and AZT were used in combinatio n against TK- HSV-1, TK- HSV-2 and TK- VZV strains, a pronounced inhib ition of viral replication was observed. This potentiating effect was not seen if AZT was combined with ACV or GCV.