HEPT DERIVATIVES - 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYLURACIL (MKC-442)

Authors
BABA M TANAKA H MIYASAKA T YUASA S UBASAWA M WALKER RT DECLERCQ E
Citation
M. Baba et al., HEPT DERIVATIVES - 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYLURACIL (MKC-442), Nucleosides & nucleotides, 14(3-5), 1995, pp. 575-583
Citations number
18
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
575 - 583
Database
ISI
SICI code
0732-8311(1995)14:3-5<575:HD-6(>2.0.ZU;2-Q
Abstract
The 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivativ es have been found to be potent and specific inhibitors of human immun odeficiency virus type 1 (HIV-1) replication in vitro. Among the compo unds, MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil) has recently been chosen as a candidate for clinical efficacy and safety studies i n patients with the acquired immune deficiency syndrome (AIDS).