ACYCLIC NUCLEOTIDES RELATED TO CLITOCINE - SYNTHESIS AND ANTI-HIV ACTIVITY

Authors
FRANCHETTI P CAPPELLACCI L SHEIKHA GA GRIFANTINI M LOI AG DEMONTIS A SPIGA MG LACOLLA P
Citation
P. Franchetti et al., ACYCLIC NUCLEOTIDES RELATED TO CLITOCINE - SYNTHESIS AND ANTI-HIV ACTIVITY, Nucleosides & nucleotides, 14(3-5), 1995, pp. 607-610
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
607 - 610
Database
ISI
SICI code
0732-8311(1995)14:3-5<607:ANRTC->2.0.ZU;2-L
Abstract
The syntheses and antiviral activity of analogues of the anti-HIV agen ts PMEA, PMEDAP, (R)-PMPA, (R)-PMPDAP are described. In these analogue s the adenine moiety is replaced by 4,6-diamino-5-nitro-pyrimidine (th e aglycon of clitocine) or 2,4,6-triamino-5-nitro-pyrimidine. The synt hesis of similar acyclic phosphonates related to PMEG and (R)-2'-methy l-PMEG is also reported. Some compounds proved to be active as anti-HI V agents.