SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-FLUORO-2-THIOCYTOSINE NUCLEOSIDES

Authors
BRETNER M BALINSKA M KRAWIEC K KIERDASZUK B SHUGAR D KULIKOWSKI T
Citation
M. Bretner et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-FLUORO-2-THIOCYTOSINE NUCLEOSIDES, Nucleosides & nucleotides, 14(3-5), 1995, pp. 657-660
Citations number
4
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
657 - 660
Database
ISI
SICI code
0732-8311(1995)14:3-5<657:SABO5N>2.0.ZU;2-U
Abstract
Two pathways are described for the synthesis of the 2'-deoxynucleoside s of 2-thiocytosine and 5-fluoro-2-thiocytosine: (a) by nucleoside con densation, (b) by amination of the corresponding nucleosides of 2,4-di thiouracil. Biological activities vs two cell systems are described. T he nucleosides are moderate to weak substrates of deoxycytidine kinase and, partly as a result of this, reasonable good inhibitors of the en zyme