3-DIMENSIONAL CELL-CULTURES AS A MODEL SYSTEM TO EVALUATE THE BIOLOGICAL-ACTIVITY OF GEMCITABINE (2',2'-DIFLUORO-2'DEOXYCYTIDINE)

Authors
PETERS GJ SMITSKAMPWILMS E VEERMAN G PIZAO PE VANHAPEREN VWTR PINEDO HM
Citation
Gj. Peters et al., 3-DIMENSIONAL CELL-CULTURES AS A MODEL SYSTEM TO EVALUATE THE BIOLOGICAL-ACTIVITY OF GEMCITABINE (2',2'-DIFLUORO-2'DEOXYCYTIDINE), Nucleosides & nucleotides, 14(3-5), 1995, pp. 661-664
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
661 - 664
Database
ISI
SICI code
0732-8311(1995)14:3-5<661:3CAAMS>2.0.ZU;2-Q
Abstract
The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to >10, 000 (colon cancer) fold higher in monolayer compared to three-dimensio nal multilayer cell cultures. This selectivity was related to marked d ifferences in dFdC activation and effects on ribonucleotides.