SYNTHESIS AND BROAD-SPECTRUM ANTIVIRAL ACTIVITY IN MICE OF CERTAIN ALKYL, ALKENYL AND RIBOFURANOSYL DERIVATIVES OF 7-DEAZAGUANINE

A series of alkyl, alkenyl and beta-D-ribofuranosyl derivatives of 7-d eazaguanine were synthesized and their ability to inhibit certain RNA virus infections was assessed in mice. 8-Chloro-7-deazaguanosine (6) p rotected the majority of mice infected intraperitoneally (i.p.) with b enzi, encephalomyocarditis, San Angelo, or Semliki Forest virus at dos es as low as 50 mg/kg/day. It was also orally active.