AN IMPROVED SYNTHESIS OF N-6-(6-AMINOHEXYL)FAD

Authors
SALEH A COMPERNOLLE F JANSSEN G
Citation
A. Saleh et al., AN IMPROVED SYNTHESIS OF N-6-(6-AMINOHEXYL)FAD, Nucleosides & nucleotides, 14(3-5), 1995, pp. 689-692
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
689 - 692
Database
ISI
SICI code
0732-8311(1995)14:3-5<689:AISON>2.0.ZU;2-Y
Abstract
We report an improved synthesis of N-6-(6-aminohexyl)FAD (1) using an efficient one-pot conversion of inosine to the N-trifluoroacetyl prote cted N-6-(6-aminohexyl)adenosine 3. The 5'-O-phosphorylated AMP deriva tive 4, activated as the imidazolide, was coupled with commercial sodi um riboflavin phosphate by using 18-crown-6 in DMF.