SYNTHESIS AND PROPERTIES OF MESSENGER-RNA 5'-CAP ANALOGS WITH 7-METHYLGUANINE REPLACED BY BENZIMIDAZOLE OR 3-METHYLBENZIMIDAZOLE

Authors
CHLEBICKA L WIECZOREK Z STOLARSKI R STEPINSKI J DARZYNKIEWICZ E SHUGAR D
Citation
L. Chlebicka et al., SYNTHESIS AND PROPERTIES OF MESSENGER-RNA 5'-CAP ANALOGS WITH 7-METHYLGUANINE REPLACED BY BENZIMIDAZOLE OR 3-METHYLBENZIMIDAZOLE, Nucleosides & nucleotides, 14(3-5), 1995, pp. 771-775
Citations number
7
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
771 - 775
Database
ISI
SICI code
0732-8311(1995)14:3-5<771:SAPOM5>2.0.ZU;2-F
Abstract
Several new analogues of the mRNA 5'-cap structure, m(7)G(5')p(n)(5')N , with n=2-4, have been synthesized in which the m(7)G component is re placed by 1-(beta-D-ribofuranosyl)benzimidazole (RBz) or 3-methyl-RBz. The latter, like m(7)G, has a positively charged imidazole ring and i s likewise fluorescent. All compounds have been characterized by vario us physico-chemical and enzymatic criteria, and by H-1 and P-31 NMR, s pectroscopy.