BIS(S-ACYL-2-THIOETHYL)ESTERS OF 2',3'-DIDEOXYADENOSINE 5'-MONOPHOSPHATE ARE POTENT ANTI-HIV AGENTS IN CELL-CULTURE

Authors
PERIGAUD C GOSSELIN G BENZARIA S GIRARDET JL MAURY G PELICANO H AUBERTIN AM KIRN A IMBACH JL
Citation
C. Perigaud et al., BIS(S-ACYL-2-THIOETHYL)ESTERS OF 2',3'-DIDEOXYADENOSINE 5'-MONOPHOSPHATE ARE POTENT ANTI-HIV AGENTS IN CELL-CULTURE, Nucleosides & nucleotides, 14(3-5), 1995, pp. 789-791
Citations number
5
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
789 - 791
Database
ISI
SICI code
0732-8311(1995)14:3-5<789:BO25>2.0.ZU;2-M
Abstract
It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV ac tivity in cell culture. Thus, compared with the parent nucleoside, a d ecrease of 3 or 4 orders of magnitude was observed in the EC(50) value s for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which m akes this compound as active as AZT.