A. Guzaev et al., A GENERAL-APPROACH FOR THE HYDROXY GROUP FUNCTIONALIZATION OF SYNTHETIC OLIGONUCLEOTIDES, Nucleosides & nucleotides, 14(3-5), 1995, pp. 833-837
Generally applicable non-nucleosidic solid supports and phosphoramidit
e building blocks that enable attachment of various tethers to the hyd
roxy groups of oligonucleotides were prepared. The key feature of the
structure of these reagents is an ester bond of moderate reactivity wh
ich allows postsynthetic introduction of tethers by reaction with subs
tituted alkylamines.