CHEMICAL SYNTHESIS OF RNA-FRAGMENT ANALOGS THAT HAVE PHOSPHOROTHIOATELINKAGES OF IDENTICAL CONFIGURATION

Authors
ALMER H STAWINSKI J STROMBERG R
Citation
H. Almer et al., CHEMICAL SYNTHESIS OF RNA-FRAGMENT ANALOGS THAT HAVE PHOSPHOROTHIOATELINKAGES OF IDENTICAL CONFIGURATION, Nucleosides & nucleotides, 14(3-5), 1995, pp. 879-881
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
879 - 881
Database
ISI
SICI code
0732-8311(1995)14:3-5<879:CSORAT>2.0.ZU;2-B
Abstract
Oligouridine all-Rp-phosphorothioates were synthesized using the H-pho sphonate approach followed by silfurisation with S-8 and treatment wit h nuclease P1. The degree of stereoselection in the couplings is repor ted for different 2'-O-silyl protecting groups. The influence of the h eterocyclic base was also investigated.