APPROACHES TO ENHANCE THE BINDING-AFFINITY AND NUCLEASE STABILITY OF TRIPLEX FORMING OLIGONUCLEOTIDES

Authors
JAYARAMAN K DURLAND RH RAO TS REVANKAR GR BODEPUDI V CHAUDHARY N GUYCAFFEY J
Citation
K. Jayaraman et al., APPROACHES TO ENHANCE THE BINDING-AFFINITY AND NUCLEASE STABILITY OF TRIPLEX FORMING OLIGONUCLEOTIDES, Nucleosides & nucleotides, 14(3-5), 1995, pp. 951-955
Citations number
4
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
951 - 955
Database
ISI
SICI code
0732-8311(1995)14:3-5<951:ATETBA>2.0.ZU;2-9
Abstract
The ability of simple azole nucleosides to promote antiparallel triple r formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhanci ng cellular uptake and stability of oligonucleotides.