OLIGONUCLEOTIDE CONJUGATES - ALTERATION OF THE PHARMACOKINETIC PROPERTIES OF ANTISENSE AGENTS

Authors
MANOHARAN M TIVEL KL ANDRADE LK MOHAN V CONDON TP BENNETT CF COOK PD
Citation
M. Manoharan et al., OLIGONUCLEOTIDE CONJUGATES - ALTERATION OF THE PHARMACOKINETIC PROPERTIES OF ANTISENSE AGENTS, Nucleosides & nucleotides, 14(3-5), 1995, pp. 969-973
Citations number
20
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
969 - 973
Database
ISI
SICI code
0732-8311(1995)14:3-5<969:OC-AOT>2.0.ZU;2-0
Abstract
Cholic acid, cholesterol, several polyamines and polyethylene glycols were conjugated to antisense oligonucleotides targeted to human or mur ine intercellular adhesion molecule-1 (ICAM-1) mRNA to study their eff ects on cellular absorption.