USE OF BIOREVERSIBLE PHOSPHATE PROTECTING GROUPS FOR THE INTRACELLULAR DELIVERY OF ANTISENSE OLIGODEOXYRIBONUCLEOTIDES

Authors
BARBER I RAYNER B IMBACH JL
Citation
I. Barber et al., USE OF BIOREVERSIBLE PHOSPHATE PROTECTING GROUPS FOR THE INTRACELLULAR DELIVERY OF ANTISENSE OLIGODEOXYRIBONUCLEOTIDES, Nucleosides & nucleotides, 14(3-5), 1995, pp. 1083-1085
Citations number
4
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
3-5
Year of publication
1995
Pages
1083 - 1085
Database
ISI
SICI code
0732-8311(1995)14:3-5<1083:UOBPPG>2.0.ZU;2-N
Abstract
The aim of this work was to design phosphorothioate oligonucleotides, the negative charges of which are temporarily masked by a group which facilitates the cellular uptake of these analogues. Then, selective re moval of this group by enzymes normally present in the cells will deli ver intracellularly the intact charged phosphorothioate oligomers able to hybridize to their complementary RNA targets and to elicit RNase H activity.