Mr. Duncan et al., INFLUENCE OF SURFACTANTS UPON PROTEIN PEPTIDE ADSORPTION TO GLASS ANDPOLYPROPYLENE, International journal of pharmaceutics, 120(2), 1995, pp. 179-188
This paper explores the use of surfactants as a pharmaceutical excipie
nt to reduce adsorptive lasses of protein/peptide drugs. The predomina
nt adsorption mechanism for protein/peptide drugs is shown to change w
ith the surface and conditions of study. In the presence of surfactant
s, where the surfactant-surface interaction is greater than the surfac
e-protein/peptide interaction, drug adsorption is reduced and/or elimi
nated. Anionic (sodium dodecyl sulfate), cationic (dodecyltrimethylamm
onium chloride and benzalkonium chloride) and nonionic surfactants (Po
lysorbate 20 and Poloxamer 188) are evaluated as possible protein/pept
ide adsorption controlling excipients. For protein/peptide adsorption
onto glass, where an electrostatic interaction predominates, only the
most hydrophobic surfactants (Polysorbate 20 and benzalkonium chloride
) were significantly effective. Protein/peptide adsorption to polyprop
ylene, where a hydrophobic/dehydration mechanism predominates, allows
additional surface-active agents to be effective in reducing drug adso
rption.