ACUTE TUBULOINTERSTITIAL NEPHRITIS AND UV EITIS SYNDROME (TINU SYNDROME)

For 10 weeks a 25-year-old man had been suffering from tiredness, fati gue, nausea and a 16 kg weight loss. Erythrocyte sedimentation rate (8 3/133 mm), serum C-reactive protein (5.5 mg/dl) and creatinine (5.05 m g/dl) were all elevated. He also had proteinuria (1120 mg daily), ster ile leukocytosis and a creatinine clearance of 10 ml/min. Renal biopsy showed interstitial nephritis and bone marrow biopsy revealed non-cas eous epithelioid-cell granulomas. 14 days after admission he developed acute iritis in the right eye. Other causes having been excluded, the diagnosis of tubulo-intestinal nephritis with uveitis (TINU syndrome) was made. The clinical symptoms and laboratory findings improved with in a few days of the start of glucocorticoid treatment (initially, 100 mg prednisone daily, reduced to 5 mg within 30 days). The patient was discharged after 8 days in good general condition.