POSSIBLE ROLE OF HERPES-SIMPLEX VIRUS IN THE ORIGIN OF POSNER-SCHLOSSMAN SYNDROME

PURPOSE/METHODS: We conducted this study to determine if the herpesvir uses are possible etiologic agents in Posner-Schlossman syndrome. We a spirated aqueous humor samples from three patients during acute attack s of the syndrome. Ten normal aqueous humor specimens from patients un dergoing cataract surgery were used as controls. DNA was extracted and subjected to polymerase chain reaction amplification and Southern blo t hybridization. RESULTS/CONCLUSION: All three specimens were positive for amplified genomic fragments of herpes simplex virus and negative for varicellazoster virus and cytomegalovirus. Ten normal aqueous spec imens were negative for all three. Herpes simplex virus may play a rol e in the origin of Posner-Schlossman syndrome.