CLINICO-PATHOGENETIC FORMS OF EXTRASYSTOL IC ARRHYTHMIA AND PRINCIPLES OF THEIR DIFFERENTIAL TREATMENT

Acute drug tests with verapamil and blockers of rapid sodium channels were carried out in 90 patients with organic forms of extrasystolic ar rhythmia. according to antiarrhythmic efficacy of tested drugs (used s eparately or In combinations) 3 clinico-pathogenetic forms of arrhythm ia could be distinguished: calcium dependent (39%), sodium dependent ( 32.2%) and mixed calcium-sodium dependent (20%). In 8,8% of patients p athogenetic form of arrhythmia could not be determined. Clinical exped iency of determination of a form of arrhythmia was supported by result s of courses of antiarrhythmic therapy. The following therapy was effe ctive in separate forms of arrhythmia: In calcium dependent combinatio n of verapamil, magnesium and potassium; in sodium dependent - blocker s of rapid sodium channels, beta-adrenoblockers or amiodarone; and In calcium-sodium dependent - combination of verapamil, rapid sodium chan nels blockers and magnesium.