INFLUENCE OF MORPHOFUNCTIONAL STATE OF LE FT-VENTRICULAR MYOCARDIUM ON HYPOTENSIVE EFFECT OF LONG-ACTING NIFEDIPINE IN PATIENTS WITH ARTERIAL-HYPERTENSION

Efficacy of prolonged action nifedipine (20 mg once daily) was studied in 44 patients with stable arterial hypertension. Patients were divid ed into groups according to end diastolic left ventricular dimension a nd cardiac output obtained by echocardiography, Optimal blood pressure decrease was achieved In patients with left ventricular end=diastolic dimension 5 cm or more and cardiac output equal to or exceeding 5.5 l /min, Hypotensive effect of nifedipine rose when the dose was increase d up to 40 mg/day. Long acting nifedipine produced regulatory action o n hemodynamics in arterial hypertension.