CYCLIN-E IS EXPRESSED IN NEURONS AND FORMS COMPLEXES WITH CDK5

Authors
MIYAJIMA M NORNES HO NEUMAN T
Citation
M. Miyajima et al., CYCLIN-E IS EXPRESSED IN NEURONS AND FORMS COMPLEXES WITH CDK5, NeuroReport, 6(8), 1995, pp. 1130-1132
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
6
Issue
8
Year of publication
1995
Pages
1130 - 1132
Database
ISI
SICI code
0959-4965(1995)6:8<1130:CIEINA>2.0.ZU;2-Y
Abstract
EXPRESSION Of cyclin dependent kinase cdk5 and its regulator p35 has b een shown in the cytoplasm of adult neurons. Here we demonstrate that another potential regulator of cdk5, cyclin E, is expressed in the ner vous system and forms complexes with cdk5. Western blot analyses ident ifies expression of two forms of cyclin E in the mouse nervous system with the 56 kDa form mainly expressed in neurons and 51 kDa form expre ssed in astrocytes and oligodendrocytes.