NEURAL CELL-ADHESION MOLECULE (N-CAM) DISTRIBUTION MAY PREDICT THE EFFECT OF NEUROTOXINS ON THE BRAIN

Authors
USHAKOVA GA BEREZIN VA SKIBO GG
Citation
Ga. Ushakova et al., NEURAL CELL-ADHESION MOLECULE (N-CAM) DISTRIBUTION MAY PREDICT THE EFFECT OF NEUROTOXINS ON THE BRAIN, Toxicon, 33(4), 1995, pp. 577-581
Citations number
12
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
33
Issue
4
Year of publication
1995
Pages
577 - 581
Database
ISI
SICI code
0041-0101(1995)33:4<577:NCM(DM>2.0.ZU;2-K
Abstract
The neural cell adhesion molecule (N-CAM) is a convenient neurospecifi c marker for investigating the effects of neurotoxins on cell migratio n, cell recognition and differentiation of neurons during development. In this report, we discuss the developmental toxicity of valproic aci d studied by two different approaches (the immunochemical detection of N-CAM content and polypeptide composition, and immunohistochemical an alysis of N-CAM topography). Immunohistochemical analysis of distribut ion of N-CAM as a surface marker on the neural cells predicted the eff ect of the neurotoxin.