SUCCESSFUL LIVER TREATMENT OF A JUVENILE GRANULOSA-CELL TUMOR IN A 4-YEAR-OLD CHILD BY REGIONAL DEEP HYPERTHERMIA, SYSTEMIC CHEMOTHERAPY, AND IRRADIATION

Juvenile granulosa cell tumors (JGCT) of the ovary are rare in childre n and adolescents. About 90% are diagnosed in early-stage FIGO I with favorable prognosis. More advanced stages (FIGO II-IV) have a poor cli nical outcome and chemotherapy alone cannot avoid tumor progression. R egional deep hyperthermia (RHT) induced by microwave technique has bee n established as an additional modality for treatment of different tum ors, However, in cases with liver involvement there are technical prob lems which have not yet been solved. We report on a 4-year-old child w ho suffered from diffuse liver metastases 10 months after JGCT of the left ovary. After chemotherapy including ifosfamide, etoposide, and ca rboplatin in combination with RHT and consolidation radiotherapy, the patient has been in complete remission for 1 year of follow-up. This C ase Report indicates the feasibility of combining surgery, chemotherap y, hyperthermia, and radiation therapy (which can also be an effective treatment modality for advanced granulosa cell tumor) for the treatme nt of liver metastases of JGCT, but does not allow comparisons of thes e treatments. (C) 1995 Academic Press, Inc.